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KMID : 0387820020090010009
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Clinical Pediatric Hematology-Oncology
2002 Volume.9 No. 1 p.9 ~ p.20
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Epidemiolohy and Clinical Characteristics of Childhood Acute Lymphoblastic Leukemia in Korea
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Lee Kwang-Chul
Kang Im-Joo
Kang Shin-Heh
Koo Hong-Hoe
Kook Hoon
Kim Kr-Young
Kim Moon-Kyu
Kim Soon-Kyum
Kim Hack-Ki
Kim Hwang-Min
Kim Heung-Sik
Nam Seung-Kon
Moon Hyung-Nam
Park Kyung-Duk
Park Sae-Myung
Park Jae-Sun
Park Jong-Young
Park Hyun-Jin
Seh Won-Suk
Seo Jong-Jin
Sung Ki-Woong
Shin Sang-Man
Shin Hee-Young
Shim Tae-Sub
Ahn Don-Hee
Ahn Hyo-Seop
Yang Chang-Hyun
Yang Eun-Suk
Woo Chan-Wook
Ryu Kyung-Ha
Yoo Eun-Sun
Lyu Chuhl-Joo
Lee Kun-Soo
Lee Soon-Yong
Lee Young-Ho
Lee Hahng
Lim Young-Tak
Im Ho-Jun
Cho Bin
Cho Hyun-Sang
Choi Kyu-Chul
Choi Doo-Young
Choi Sang-Wook
Choi Young-Mook
Hah Jeong-Ok
Hwang Pyoung-Han
Hwang Tae-Ju
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Abstract
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Purpose:Acute lymphoblastic leukemia (ALL) accounts for approximately 75% of all cases of childhood leukemia. We investigated epidemiology, clinical and laboratory features and treatment outcome of the children with ALL in Korea during recent 5 years.
Methods:One thousand forty nine patients were enrolled between January 1994 and December 1998 from 37 major ospitals in Korea. The data regarding the clinical and laboratory features including age, WBC counts at diagnosis, immunophenotype, morphology, cytogenetics and treatment outcome of patients were analyzed retrospectively by review of patient’s medical records. Kaplan-Meier survival curves were constructed. The differences between groups analyzed by log-rank test.
Results:There were 597 males and 452 females. The distribution between the age 2 and 5 years is most common in 46.1%. The annual incidence rate per 100,000 population varied from 1.6 to 2.2. The 5 year event free survival (EFS) rates according to good prognostic factors were as follows: 67% bet ween 1-9 year of age at diagnosis, 69% in under 10,000/mm3of initial WBC count, 74% in early pre-B cell CALLA ( ) immunophenotype, 65% in L3 morphology, 68% in no CNS invasion. Most of patients were treated by CCG treatment protocol. The 5 year EFS was 63%. Main complications were sepsis (21.8%) and hemorrhage (12.5%). The relapse rate was 15.6%. The common causes of death were sepsis, DIC, pneumonia, relapse.
Conclusion:Our results could provide the most recent and important information about acute lymphoblastic leukemia of children in Korea.
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KEYWORD
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Acute lymphoblastic leukemia, Epidemiolohy, Event free survival, Children
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